Starting lineup
4-2-5 Nickel
Full roster
| # | Pct | |||||
|---|---|---|---|---|---|---|
| 1 | Jimmy Garoppolo›low volume | QB | 6 / 5 | 351 | 85.0 | 97 |
| 2 | Robbie Gould› | K | 16 / 0 | 75 | 84.7 | 93 |
| 3 | Garrett Celek›low volume | TE | 16 / 7 | 788 | 73.7 | 90 |
| 4 | George Kittle› | TE | 15 / 8 | 598 | 60.0 | 81 |
| 5 | Kendrick Bourne›low volume | WR | 11 / 1 | 317 | 55.5 | 57 |
| 6 | Bradley Pinion› | P | 16 / 9 | 227 | 53.4 | 63 |
| 7 | Matt Breida› | RB | 16 / 4 | 478 | 50.1 | 53 |
| 8 | Pierre Garcon› | WR | 8 / 7 | 430 | 49.5 | 48 |
| 9 | Marquise Goodwin› | WR | 16 / 14 | 770 | 48.2 | 46 |
| 10 | Kyle Juszczyk›low volume | RB | 14 / 4 | 461 | 44.8 | 38 |
| 11 | Trent Taylor› | WR | 15 / 5 | 566 | 43.9 | 40 |
| 12 | Carlos Hyde› | RB | 16 / 15 | 786 | 34.7 | 9 |
| 13 | Aldrick Robinson›low volume | WR | 16 / 4 | 522 | 26.2 | 9 |
| 14 | C.J. Beathard› | QB | 7 / 6 | 391 | 13.4 | 6 |
| 15 | Dontae Johnson› | CB | 16 / 16 | 1,223 | — | — |
| 16 | Daniel Kilgore› | OL | 16 / 16 | 1,170 | — | — |
| 17 | Brandon Fusco› | OL | 16 / 16 | 1,149 | — | — |
| 18 | Laken Tomlinson› | OL | 15 / 15 | 1,089 | — | — |
| 19 | Joe Staley› | OL | 15 / 14 | 1,049 | — | — |
| 20 | DeForest Buckner› | iDL | 16 / 15 | 950 | — | — |
| 21 | Brock Coyle› | LB | 16 / 10 | 837 | — | — |
| 22 | Eric Reid› | S | 13 / 11 | 804 | — | — |
| 23 | Ahkello Witherspoon› | CB | 12 / 9 | 771 | — | — |
| 24 | Solomon Thomas› | EDGE | 14 / 13 | 754 | — | — |
| 25 | Cassius Marsh› | EDGE | 15 / 11 | 722 | — | — |
| 26 | Trent Brown› | OL | 10 / 10 | 703 | — | — |
| 27 | Adrian Colbert› | S | 14 / 8 | 698 | — | — |
| 28 | Earl Mitchell› | iDL | 16 / 10 | 697 | — | — |
| 29 | Eli Harold› | LB | 16 / 10 | 683 | — | — |
| 30 | Jaquiski Tartt› | S | 9 / 8 | 679 | — | — |
| 31 | K'Waun Williams› | CB | 14 / 11 | 643 | — | — |
| 32 | Reuben Foster› | LB | 10 / 9 | 564 | — | — |
| 33 | Zane Beadles› | OL | 16 / 6 | 466 | — | — |
| 34 | Jimmie Ward› | S | 7 / 5 | 465 | — | — |
| 35 | Dekoda Watson› | LB | 14 / 13 | 376 | — | — |
| 36 | Sheldon Day› | iDL | 12 / 3 | 364 | — | — |
| 37 | Elvis Dumervil› | EDGE | 16 / 1 | 350 | — | — |
| 38 | Arik Armstead› | EDGE | 6 / 5 | 332 | — | — |
| 39 | Logan Paulsen› | TE | 14 / 1 | 298 | — | — |
| 40 | Elijah Lee› | LB | 14 / 13 | 292 | — | — |
| 41 | Leon Hall› | CB | 9 / 0 | 258 | — | — |
| 42 | Leger Douzable› | EDGE | 5 / 5 | 243 | — | — |
| 43 | Tank Carradine› | EDGE | 8 / 0 | 229 | — | — |
| 44 | Louis Murphy› | WR | 7 / 1 | 228 | — | — |
| 45 | Raheem Mostert› | RB | 11 / 9 | 219 | — | — |
| 46 | Erik Magnuson› | OL | 4 / 3 | 198 | — | — |
| 47 | Dexter McCoil› | S | 10 / 10 | 193 | — | — |
| 48 | D.J. Jones› | iDL | 9 / 0 | 190 | — | — |
| 49 | Mark Nzeocha› | LB | 10 / 10 | 188 | — | — |
| 50 | Ronald Blair› | iDL | 6 / 1 | 165 | — | — |
| 51 | Aaron Lynch› | EDGE | 7 / 0 | 158 | — | — |
| 52 | Greg Mabin› | CB | 7 / 2 | 150 | — | — |
| 53 | Victor Bolden› | WR | 9 / 4 | 149 | — | — |
| 54 | Kyle Nelson› | LS | 16 / 0 | 148 | — | — |
| 55 | Lorenzo Jerome› | CB | 4 / 1 | 116 | — | — |
| 56 | Asa Jackson› | CB | 4 / 3 | 72 | — | — |
| 57 | Cole Hikutini› | TE | 4 / 2 | 70 | — | — |
| 58 | Tyvis Powell› | CB | 3 / 3 | 69 | — | — |
| 59 | Antone Exum› | S | 2 / 1 | 64 | — | — |
| 60 | Garry Gilliam› | OL | 8 / 0 | 64 | — | — |
| 61 | Darrell Williams› | OL | 7 / 0 | 37 | — | — |
| 62 | Max McCaffrey› | WR | 5 / 0 | 31 | — | — |
| 63 | Pita Taumoepenu› | LB | 2 / 0 | 28 | — | — |
| 64 | Jeremy McNichols› | RB | 2 / 1 | 26 | — | — |
| 65 | Tim Barnes› | OL | 1 / 0 | 2 | — | — |
| 66 | Vinnie Sunseri› | CB | 0 / 0 | — | — | — |
| 67 | Kaleb Ramsey› | iDL | 0 / 0 | — | — | — |
| 68 | Will Davis› | CB | 0 / 0 | — | — | — |
| 69 | Don Jones› | CB | 0 / 0 | — | — | — |
| 70 | Sean Porter› | LB | 0 / 0 | — | — | — |
| 71 | Chris Jones› | iDL | 0 / 0 | — | — | — |
| 72 | Jayson DiManche› | LB | 0 / 0 | — | — | — |
| 73 | Malcolm Smith› | LB | 0 / 0 | — | — | — |
| 74 | Sen'Derrick Marks› | iDL | 0 / 0 | — | — | — |
| 75 | Andrew Gardner› | OL | 0 / 0 | — | — | — |
| 76 | Tim Hightower› | RB | 0 / 0 | — | — | — |
| 77 | Cameron Hunt› | OL | 0 / 0 | — | — | — |
| 78 | Channing Stribling› | CB | 0 / 0 | — | — | — |
| 79 | Andrew Lauderdale› | OL | 0 / 0 | — | — | — |
| 80 | B.J. Johnson› | WR | 0 / 0 | — | — | — |
| 81 | Chanceller James› | CB | 0 / 0 | — | — | — |
| 82 | Ben Boulware› | LB | 0 / 0 | — | — | — |
| 83 | Noble Nwachukwu› | EDGE | 0 / 0 | — | — | — |
| 84 | Donavin Newsom› | LB | 0 / 0 | — | — | — |
| 85 | Nick Mullens› | QB | 0 / 0 | — | — | — |
| 86 | Tyler McCloskey› | RB | 0 / 0 | — | — | — |
| 87 | Jimmie Gilbert› | LB | 0 / 0 | — | — | — |
| 88 | Zach Franklin› | CB | 0 / 0 | — | — | — |
| 89 | JP Flynn› | OL | 0 / 0 | — | — | — |
| 90 | Joe Williams› | RB | 0 / 0 | — | — | — |
| 91 | Jarnor Jones› | CB | 0 / 0 | — | — | — |
| 92 | Boseko Lokombo› | LB | 0 / 0 | — | — | — |
| 93 | Joshua Garnett› | OL | 0 / 0 | — | — | — |
| 94 | Pace Murphy› | OL | 0 / 0 | — | — | — |
| 95 | Cole Wick› | TE | 0 / 0 | — | — | — |
| 96 | Prince Charles Iworah› | CB | 0 / 0 | — | — | — |
| 97 | Aaron Burbridge› | WR | 0 / 0 | — | — | — |
| 98 | Trovon Reed› | CB | 0 / 0 | — | — | — |
| 99 | DeAndre Smelter› | WR | 0 / 0 | — | — | — |
| 100 | DeAndre Carter› | WR | 0 / 0 | — | — | — |